Lessons for clinical trials from natalizumab in multiple sclerosis.
نویسنده
چکیده
http://bmj.com/cgi/content/full/332/7538/416 Updated information and services can be found at: These include: References http://bmj.com/cgi/content/full/332/7538/416#BIBL This article cites 16 articles, 14 of which can be accessed free at: Rapid responses http://bmj.com/cgi/eletter-submit/332/7538/416 You can respond to this article at: http://bmj.com/cgi/content/full/332/7538/416#responses free at: One rapid response has been posted to this article, which you can access for
منابع مشابه
A meta-analysis on the efficacy and tolerability of natalizumab in relapsing multiple sclerosis
INTRODUCTION Natalizumab is a new humanized monoclonal antibody used in multiple sclerosis (MS). The aim of this meta-analysis was to evaluate the efficacy and tolerability of this drug in relapsing MS. PubMed, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials were searched for studies that investigated the efficacy and/or tolerability of natalizumab in MS. Data were co...
متن کاملLessons learned from fatal progressive multifocal leukoencephalopathy in a patient with multiple sclerosis treated with natalizumab.
OBJECTIVE To describe the clinical, radiological, and histopathological features of a fatal case of progressive multifocal leukoencephalopathy (PML) in a patient with multiple sclerosis treated with natalizumab. We will use this case to review PML risk stratification and diagnosis. DESIGN Case report. SETTING Tertiary referral center hospitalized care. PATIENT A 55-year-old, JC virus (JCV...
متن کاملEfficacy and safety of natalizumab in multiple sclerosis: interim observational programme results
BACKGROUND Clinical trials established the efficacy and safety of natalizumab. Data are needed over longer periods of time and in the clinical practice setting. OBJECTIVE To evaluate long-term safety of natalizumab and its impact on annualised relapse rate and Expanded Disability Status Scale (EDSS) progression in patients with relapsing-remitting multiple sclerosis (RRMS). METHODS The Tysa...
متن کاملNatalizumab for Multiple Sclerosis: A Case in Point for the Impact of Translational Neuroimmunology.
Advances in translational neuroimmunology over the last two decades have revolutionized the treatment of relapsing forms of multiple sclerosis. A pathological hallmark of multiple sclerosis is the presence of leukocytes in the areas of disease activity in the CNS. Natalizumab inhibits the trafficking of lymphocytes from the blood into the brain and spinal cord by blocking the adhesion molecule ...
متن کاملDisease Modifying Agents for Multiple Sclerosis
OBJECTIVE To summarize major clinical trials which evaluate the efficacy and safety data of approved disease modifying agents for the treatment of various types of multiple sclerosis. DATA SOURCES A MEDLINE (1966 to August 2008) search of clinical trials using the terms multiple sclerosis, interferon, glatiramer, mitoxantrone and natalizumab was performed. A manual bibliographic search was al...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- BMJ
دوره 332 7538 شماره
صفحات -
تاریخ انتشار 2006